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KMID : 0360419730090020017
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Korean Journal of Pharmacology
1973 Volume.9 No. 2 p.17 ~ p.27
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Effect of Caerulein on the Pancreatic and Gastric Secretion in Rats Studied by Means of Duodenal and Gastric Perfusion
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Abstract
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Modifying the technique described by Schmidt, et al. (1972) the duodenum and stomach of female rats were perfused separately and contiunously with saline solution under urethane anesthesia. Secretory response of caerulein (Prof. V. Erspamer, F.I. 6934 Caerulein, Farmitalia, Italia), a gastrin or CCK-PZ like peptide, on acid, pepsin, bicarbonate and amylase were studied with and without simultaneous administration of secretin, CCK-PZ or other agents known secretory suppressives.
A significant increase of acid, pepsin and amylase output was induced by intravenous infusion of caerulein. The response of acid secretion by caerulein in doses of 140 ng/100g/hr was equivalent to the response of histamine in the doses of 280 ㎍/100g/hr and on a weight basis the potency of caerulein was approximately 2,000 times greater than histamine in rats. Acid secretory response of caerulein in the doses of 140 ng/100 g/hr was inhibited by simultaneous infusion of secretin in the doses of 0.2 u/100g/hr, and the acid response was partly inhibited by concomitant infusion of histamine in the doses of 280 ㎍/100 g/hr, but the response was enhanced by infusion of CCK-PZ in the doses of 0.2 u/100 g/hr. The secretory response of both aicd and enzymes were inhibited following administration of atropine in doses of 0.2 mg/100 g, but the response were not affected by hexamethonium in doses of 0.5 mg/100 g.
In summary, it is concluded that caerulein is every effective in an increase of acid, pepsin and amylase secretion in rats through, possibly in part, the muscarinic and/or histaminic mechanism (s).
(Supported by funds from Medical College, Yonsei University and Yuhan Research Grant)
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